William Hetrick

William Hetrick

Professor, Psychological and Brain Sciences

Department Chair, Psychological and Brain Sciences


  • Ph.D., The Ohio State University, Clinical Psychology, 1999
  • M.A., California State University, Experimental Psychology, 1993
  • B.A., Point Loma Nazarene College, Psychology, 1987

Research interests

The Hetrick Lab is dedicated to the discovery of neurocognitive mechanisms associated with the etiology of schizophrenia and bipolar disorder and the development of innovative interventions for these syndromes.  The lab is especially interested in clinical translational science approaches that leverage basic science methods and nonhuman models to understand and ameliorate complex human issues.  The lab utilizes behavioral, cognitive, and brain imaging techniques, including electromyography (EMG), electroencephalography (EEG), and functional and structural magnetic resonance brain imaging (MRI).  We have laboratory facilities in the Department of Psychological and Brain Sciences and at Larue D. Carter Memorial Hospital, which is a teaching and research site for the IU Department of Psychiatry.  We have ongoing collaborations with the Indiana University laboratories of Drs. Brian F. O’Donnell, Aina Puce, Sharlene Newman, Olaf Sporns, Michael Jones, and Alan Breier.

Representative publications

Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics (1996)
S Akbarian, NJ Sucher, D Bradley, A Tafazzoli, D Trinh, WP Hetrick ...
Journal of Neuroscience, 16 (1), 19-30

Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients (1996)
Schahram Akbarian, James J Kim, Steven G Pothin, William P Hetrick, William E Bunney and Edward G Jones
Archives of general psychiatry, 53 (5), 425-436

P50 sensory gating ratios in schizophrenics and controls: a review and data analysis (2008)
Julie V Patterson, William P Hetrick, Nash N Boutros, Yi Jin, Curt Sandman, Hal Stern ...
Psychiatry research, 158 (2), 226-247

Event‐related potential correlates of task switching and switch costs (2005)
Paul D Kieffaber and William P Hetrick
Psychophysiology, 42 (1), 56-71

Eye gaze and individual differences consistent with learned attention in associative blocking and highlighting (2005)
John K Kruschke, Emily S Kappenman and William P Hetrick
Journal of Experimental Psychology: Learning, Memory, and Cognition, 31 (5), 830

Auditory event-related potential abnormalities in bipolar disorder and schizophrenia (2004)
BF O'donnell, JL Vohs, WP Hetrick, CA Carroll and Anantha Shekhar
International Journal of Psychophysiology, 53 (1), 45-55

Haloperidol impairs learning and error-related negativity in humans (2004)
Patrick J Zirnheld, Christine A Carroll, Paul D Kieffaber, Brian F O'donnell, Anantha Shekhar and William P Hetrick
MIT Press. 16 (6), 1098-1112

Steady state responses: electrophysiological assessment of sensory function in schizophrenia (2009)
Colleen A Brenner, Giri P Krishnan, Jenifer L Vohs, Woo-Young Ahn, William P Hetrick, Sandra L Morzorati ...
Schizophrenia bulletin, 35 (6), 1065-1077

Effects of P50 temporal variability on sensory gating in schizophrenia (1997)
Yi Jin, Steven G Potkin, Julie V Patterson, Curt A Sandman, William P Hetrick and William E Bunney Jr
Psychiatry research, 70 (2), 71-81

Steady state visual evoked potential abnormalities in schizophrenia (2005)
Giri P Krishnan, Jenifer L Vohs, William P Hetrick, Christine A Carroll, Anantha Shekhar, Marcia A Bockbrader ...
Clinical Neurophysiology, 116 (3), 614-624

Is P50 suppression a measure of sensory gating in schizophrenia? (1998)
Yi Jin, William E Bunney Jr, Curt A Sandman, Julie V Patterson, Kirsten Fleming, Jeffrey R Moenter ...
Biological psychiatry, 43 (12), 873-878

Effects of temporal variability on p50 and the gating ratio in schizophrenia: a frequency domain adaptive filter single-trial analysis (2000)
Julie V Patterson, Yi Jin, Matt Gierczak, William P Hetrick, Steven Potkin, William E Bunney ...
Archives of general psychiatry, 57 (1), 57-64

Temporal processing dysfunction in schizophrenia (2008)
Christine A Carroll, Jennifer Boggs, Brian F O’Donnell, Anantha Shekhar and William P Hetrick
Brain and cognition, 67 (2), 150-161

Structured interview for assessing perceptual anomalies (SIAPA) (1999)
William E Bunney Jr, William P Hetrick, Blynn G Bunney, Julie V Patterson, Yi Jin, Steven G Potkin ...
Schizophrenia bulletin, 25 (3), 577-592

Gender differences in gating of the auditory evoked potential in normal subjects (1996)
William P Hetrick, Curt A Sandman, William E Bunney Jr, Yi Jin, Steven G Potkin and Margaret H White
Biological psychiatry, 39 (1), 51-58

Dissertation Committee Service

Author Dissertation Title Committee
Carroll, Christine Temporal Processing in Schizophrenia: An Integrative Study of Behavioral Judgment, Motor Execution, and Quantitative Modeling (December 2007) Kruschke, K., O’Donnell, B., Sporns, O. (Co-Chair), Townsend, J., Hetrick, W (Co-Chair)
Kieffaber, Paul Components of Attentional Control in Schizophrenia (June 2006) Hetrick, W. (Co-Chair), O’Donnell, B., Kruschke, J. (Co-Chair), Sporns, O., Townsend, J.